No, I don't think it matters. My life is a series of random events meaning if at that particular moment drugs find me then I go with the flow with a few exceptions, no needles, no crack, no meth, no bath salts, no krokodil, etc.
Sometimes I go through phases of weed, sometimes it's alcohol, or maybe I meet some people at a party and get offered blow, acid, or mescaline. It's really all about the moment and if I'm feeling it or not. Mood has a lot to do with my decisions. If I'm not feeling something at that particular time then I don't do it. I've noticed that's normally when I lose it and it no longer becomes a good experience since it controls me. I think I passed the phase in my life of hard drugs and psychedelics, but really I do not go out of my way for anything, unless it finds me (Depends on the people, town, etc.)
In the scheme of things it's your life and you have the decision to make your own choices. I have addictive qualities so it's better to randomly do drugs with people I'll never see again than friends I see everyday. I've seen drugs take over people's lives, but I've also seen them change a boring night into adventure. Just sitting in someone's basement turned into seeing real-life Transformers while the walls grew vines and the grass grew four feet before my eyes. Depends what you do and how much you do. Indulge wisely my friend.