Done this route a couple times. The most traffic is between Reno and Barstow (junction with CA hwy 58).
Everything north of there will have little traffic. Susanville to Reno isint bad
The good part about this route is the ability to bail. The 20 in OR between Bend and Ontario, ID is a good spot to bail (if there is no traffic) so is the 299 (Redding to...Susanville/Alturas?) The I-80 (Sac>Reno>SLC) and CA 120 (Lee Vining>Fresno, summer only)
This entire route is amazing and beautiful, paralleling the Eastern Sierras and going through the Lassen National Forest, ending in the beautiful Mohave near Death Valley (North to south)
It can be very remote, have hardcore random weather, and lack of rides, but worth it.
Lots of hot springs and opportunities to get it away from people, pretty close to towns.
Plan on NOT doing it in the winter. The highway shuts down alot during winter storms.