I think trailers are best suited for local use. Unless you get a one wheel trailer.
If it's at all possible it's best to go from being an ultralight backpacking freak (10lb base pack weight (weight of gear not including food and water)) to then getting on a bike and adding just the gear you need to keep the bike going (oil, patch kit, pump, lock/bike alarm).
You'll have a lot more options if your bike plus gear is light enough to lift over a fence for example.
If you're ever in one of those states that corrugates the shoulders of their roads there's a good chance that even if you find a smooth track for your bicycle wheels, one of the wheels of a two wheel trailer will be hitting all the bumps.
That said, I've been on
long bike tours with group food collecting and cooking and we all took turns pulling the music trailer and the gear trailer. . . So it can be done and can be useful. (But even then i wasn't a fan of the trailers really but took my turn even so).
And a recent discovery was
jayoe, who has a super deluxe trailer setup and has done serious miles.
Alisemango used a trailer on her long trip i think. Actually,
no she didn't.
For the other extreme, look up
ed pratt who rode a unicycle around the world carrying all his gear.
I guess it depends on what you want to do! The one time i regularly used a trailer was to cart windsurfing gear to and from the windsurfing spot by the airport on Maui and i made it out of the bottom of a shopping cart.
One of my home bum friends regularly makes trailers out of child strollers from thrift stores and panniers out of back packs from thrift stores.
Unfortunately for me, lacking a certain amount of self control, the more stuff i have the capacity to carry, the more stuff i tend to try to carry!